U.S. Route 49 is a north–south United States highway. The highway’s northern terminus is in Piggott, Arkansas, at an intersection with US Route 62/Highway 1/Highway 139 (US 62/AR 1/AR 139). Its southern terminus is in Gulfport, Mississippi, at an intersection with U.S. Route 90. US 49 is approximately 515.50 miles (831 km) in length.
|West end:||US 90 at Gulfport, MS|
|North end:||US 62 / AR 1 / AR 139 at Piggott, AR|
|Highway system||NY 104 at the Canadian border in Niagara Falls, NY||States||Mississippi, Arkansas|